柯希贤

柯希贤，博士，副研究员，硕士生导师。中共党员，汉族，毕业于四川大学生物治疗国家重点实验室。贵州省医学会胸心外科学分会委员、中国抗癌协会肺癌专业委员会委员、遵义市医学会胸心外科学分会委员。Cellular oncology、Front. Cell Dev. Biol.、Front. Oncol.、Front. Genet.、Cell Cycle、PLoS One等杂志审稿人。主持国家自然科学基金1项、贵州省科技厅基础研究计划1项、

厅校级课题2项。以一作或通讯作者发表SCI论文10余篇，主编专著1部。

邮箱：kexixian@zmu.edu.cn

科研与学术工作经历

1.2017-11至现在，遵义医科大学附属医院，副研究员

2.2012-09至2016-06，四川大学，生物治疗国家重点实验室，攻读全日制博士

主持或参加科研项目

1.国家自然科学基金地区基金项目，81960532，hsa_circ_0001085/ miR-410/Gsk3β信号网络对肺癌生长及转移的作用研究，2020-01至2023-12，34万，在研，主持

2.贵州省科技厅基础研究计划，黔科合基础-ZK[2022]一般644，EIF4A3调节circ_GLS（circ_0001085）影响肺癌干性的作用研究，2022-04至2025-03，10万，在研，主持

3.遵义医科大学2017学术新苗，骨髓间充质干细胞治疗体外循环心肌缺血再灌注心肌损伤的作用及机制研究，2018-10至2020-10，6万，已结题，主持

4.遵义医科大学博士启动金，hsa_circ_0001085在非小细胞肺癌中的作用研究，2020-01至2022-12，10万，在研，主持

5.贵州省科技厅科技支撑计划，CCNB1通过FAK/Ras/MAPK信号通路调控肺腺癌转移的作用研究，2021-01至2024-03，30万，在研，参加

6.国家科技重大专项子课题，2012ZX09103301-009，新型FUS1/hIL-12 双基因共表达联合治疗肺癌一类新药的研发，2012-01至2015-12，150万，已结题，参加

代表性研究成果

期刊论文

1.Yue Yuan, Hu Liao, Qiang Pu, Xixian Ke, Xueting Hu,Yongfang Ma, Xinmei Luo, Qianqian Jiang, Yi Gong, Min Wu, Lunxu Liu*, Wen Zhu*. miR-410 induces both epithelial-mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer. Signal Transduct Target Ther., 2020, 5(1): 85.   

2.Ke Li#, Dan Sun#, Qiheng Gou, Xixian Ke, Yanqiu Gong, Yuanli Zuo, Jian Kang Zhou, Chenglin Guo, Zhichu Xia, Lunxu Liu, Qintong Li, Lunzhi Dai, Yong Peng*. Long non-coding RNA linc00460 promotes epithelial-mesenchymal transition and cell migration in lung cancer cells. Cancer Letters, 2018, 420: 80-90.   

3.Xixian Ke, Yue Yuan, Chenglin Guo, Yan Yang, Qiang Pu, Xueting Hu, Kui Tang, Xinmei Luo, Qianqian Jiang, Xiaolan Su, Lunxu Liu* , Wen Zhu*, Yuquan Wei. MiR-410 induces stemness by inhibiting Gsk3beta but upregulating beta-catenin in non-small cells lung cancer. Oncotarget, 2017, 8(7): 11356-11371.

4.Qiang Guo# , Xi-Xian Ke#, Shi-Xu Fang, Wei-Long Gao, Yong-Xiang Song, Cheng Chen*, Hong-Ling Lu*, Gang Xu*. PAQR3 inhibits non-small cell lung cancer growth by regulating the NF-κB/p53/Bax Axis. Front. Cell Dev. Biol., 2020, 8: 581919.

5.Qiang Guo# , Xi-Xian Ke# , Zhou Liu, Wei-Long Gao, Shi-Xu Fang, Cheng Chen; Yong-Xiang Song, Hao Han, Hong-Ling Lu*, Gang Xu*. Evaluation of the prognostic value of STEAP1 in lung adenocarcinoma and insights into its potential molecular pathways via bioinformatic analysis. Front. Genet., 2020, 11: 242.

6.Xixian Ke , Cheng Chen, Yongxiang Song , Qingyong Cai, Jian Li , Yang Tang, Xu Han , Wendong Qu, Anping Chen, Hui Wang , Gang Xu* , Daxing Liu* . Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells. Oncol Lett., 2019, 18(6):5871-5878.

7.Shixu Fang, Zhou Liu, Qiang Guo, Cheng Chen, Xixian Ke* and Gang Xu*. High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis. BMC Cancer, 2020; 20:870.

8.Shi Xu Fang, Cheng Chen, Qiang Guo, Xi Xian Ke, Hong Ling Lu, Gang Xu. High lncSNHG15 expression may predict poor cancer prognosis: a meta-analysis based on the PRISMA and the bio-informatics analysis. Biosci Rep., 2020, 40(7): BSR20194468.

9.Cheng Chen, Yang Tang, Wen-Dong Qu, Xu Han, Jie-Bin Zuo, Qing-Yong Cai, Gang Xu, Yong-Xiang Song*, Xi-Xian Ke*. Evaluation of clinical value and potential mechanism of MTFR2 in lung adenocarcinoma via bioinformatics. BMC Cancer, 2021, 21(1):619.

10.Yang Tang#, Maoyan Jiang#, Anping Chen , Wendong Qu, Xu Han , Jiebin Zuo, Gang Xu, Yongxiang Song*, Cheng Chen*, Xixian Ke*. Porcupine inhibitor LGK-974 inhibits Wnt/β-catenin signaling and modifies tumor-associated macrophages resulting in inhibition of the malignant behaviors of non-small cell lung cancer cells. Mol Med Rep., 2021, 24(2):550.

11.Cheng Chen#, Kui Zhai#, Yang Tang, Wendong Qu, Jiebin Zuo, Xixian Ke*, Yongxiang Song*. Thoracic endometriosis: a case report and review of the literature. Ann Palliat Med., 2021, 10(3):3500-3503.

12.Cheng Chen, Qiang Guo, Yang Tang, Wendong Qu, Jiebin Zuo, Xixian Ke, Yongxiang Song. Screening and evaluation of the role of immune genes of brain metastasis in lung adenocarcinoma progression based on the TCGA and GEO databases. J Thorac Dis., 2021, 13(8):5016-5034.

专著

现代实用肿瘤学. 盖磊，马永华，柯希贤主编.天津科学技术出版社，2020.5